定量代谢组学

定量代谢组学(Q metabolomics),是针对特定化学性质或者具有相似生理功能的一类代谢物进行检测的代谢组学方法,选择特异性的样本前处理方法,优化色谱分离及质谱条件等对这些代谢物进行最优化检测,大大提高了检测的灵敏度、准确性、特异性及重现性,确保不丢失低峰度的代谢物信息,从而对这一类代谢物的进行绝对定量研究,具有极高通量及卓越的可靠性和信息挖掘性。

同时,通过定量代谢组学研究方法检测机体收到外界扰动后体内所有代谢产物的量及其量的变化,可为疾病诊断和防治、药物开发,药效筛选、药物的独立药理等提供更加精准、可靠的量化指标。该方法具有极高通量、卓越的可靠性和信息可挖掘性,使得生物标志物的筛选过程变得简单、可靠。

我们已发表的代表文章

1) WenLian Chen, YueYing Wang, et al. Enhanced Fructose Utilization Mediated by SLC2A5 Is a Unique Metabolic Feature of Acute Myeloid Leukemia with Therapeutic Potential. Cancer Cell, 2016, 30(5): 779-91. (IF=23.2)

2) Tianlu Chen, Xiaojiao Zheng, et al. Tryptophan Predicts the Risk for Future Type 2 Diabetes. PLoS One, 2016, 11(9): e0162192. (IF=3.1)

3) Tianlu Chen, Yan Ni, et al. Branched-chain and aromatic amino acid profiles and diabetes risk in Chinese populations. Sci Rep, 2016, 6: 20594. (IF=5.2, Citations: 3)

4) Guoxiang Xie, Bingsen Zhou, et al. Lowered Circulating Aspartate is a Metabolic Feature of Human Breast Cancer. Oncotarget, 2015, 6(32), 33369-81. (IF=5.0, Citations: 3)

5) WenLian Chen, JingHan Wang, et al. A Distinct Glucose Metabolism Signature of Acute Myeloid Leukemia with Prognostic Value. Blood, 2014, 124(10): 1645-54. (IF=11.8, Citations: 16)

6) Xiaojiao Zheng, Yunping Qiu, et al. A Targeted Metabolomic Protocol for Short-Chain Fatty Acids and Branched-Chain Amino Acids. Metabolomics, 2013, 9(4): 818-27. (IF=3.7, Citations: 13)